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What Do Germans Want to Know About Skin Cancer? A Nationwide Google Search Analysis From 2013 to 2017
Conclusions: Our study provides insight into terms and fields of interest related to skin cancer relevant to the German population. Furthermore, temporal trends and courses are shown. This information could aid in the development and implementation of effective and sustainable awareness campaigns by developing information sources targeted to the population’s broad interest or by implementing new Internet campaigns.
Source: Journal of Medical Internet Research - May 2, 2018 Category: General Medicine Authors: Stefanie Seidl Barbara Schuster Melvin R üth Tilo Biedermann Alexander Zink Source Type: research

Web search data as health data? : Geographic differences, temporal trends, and topics of interest from internet search engine analyses in Germany
CONCLUSION: Web search data, given the limitations noted, are able to directly provide spatiotemporal mapping regarding the needs of the Internet-using population. They are particularly useful in situations where traditional health data are limited or unavailable.PMID:34812913 | PMC:PMC8609262 | DOI:10.1007/s00105-021-04918-x
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - November 23, 2021 Category: Dermatology Authors: S Ziehfreund L Tizek A Zink Source Type: research

Building a gold standard to construct search filters: a case study with biomarkers for oral cancer.
CONCLUSIONS: The gold standard dataset is likely to be high quality and useful for future development and evaluation of filters for OSCC studies of potential prognostic biomarkers. IMPLICATIONS: The methodology we used is generalizable to other domains requiring a reference standard to evaluate the performance of search filters. A gold standard is essential because the labels regarding relevance enable computation of diagnostic metrics, such as sensitivity and specificity. Librarians and informationists with data analysis skills could contribute to developing gold standard datasets and subsequent filters tuned for thei...
Source: Journal of the Medical Library Association : JMLA - January 4, 2015 Category: Databases & Libraries Tags: J Med Libr Assoc Source Type: research

The Prognostic and Clinical Value of CD44 in Colorectal Cancer: A Meta-Analysis
Conclusions: This meta-analysis demonstrated that CD44 overexpression might be an unfavorable prognostic factor for CRC patients and could be used to predict poor differentiation, lymph node metastasis and distant metastasis. Introduction Although therapies for colorectal cancer (CRC) has improved in recent years, colorectal cancer is still the third most common cause of cancer related death worldwide (1). Metastasis are observed in 25% of patients at initial diagnosis and approximately 50% of patients will develop metastasis (2). Presently, the outcome prediction and the therapy schedule determination of CRC patie...
Source: Frontiers in Oncology - April 29, 2019 Category: Cancer & Oncology Source Type: research

Interest in Skin Cancer in Urban Populations: A Retrospective Analysis of Google Search Terms in Nine Large German Cities.
Abstract Skin cancer is a major public health issue, which could be reduced through prevention programmes. However, prevention utilization is not very prevalent. It is therefore important to understand individuals' interest in skin cancer. Google AdWords Keyword Planner was used to identify the search volume in 9 German cities between July 2014 and June 2018. From a total of 1,203 identified keywords, 1,047 search terms were related to skin cancer, which had an overall search volume of 3,460,980. Most terms referred to "identifying skin cancer". For melanoma, the number of Google searches per 100,000 inhabitants c...
Source: Acta Dermato-Venereologica - May 9, 2019 Category: Dermatology Authors: Tizek L, Schielein MC, Rüth M, Szeimies RM, Philipp-Dormston WG, Braun SA, Hecker C, Eberlein B, Biedermann T, Zink A Tags: Acta Derm Venereol Source Type: research

Understanding Visual Search Patterns of Dermatologists Assessing Pigmented Skin Lesions Before and After Online Training
Abstract The goal of this investigation was to explore the feasibility of characterizing the visual search characteristics of dermatologists evaluating images corresponding to single pigmented skin lesions (PSLs) (close-ups and dermoscopy) as a venue to improve training programs for dermoscopy. Two Board-certified dermatologists and two dermatology residents participated in a phased study. In phase I, they viewed a series of 20 PSL cases ranging from benign nevi to melanoma. The close-up and dermoscopy images of the PSL were evaluated sequentially and rated individually as benign or malignant, while eye position ...
Source: Journal of Digital Imaging - November 7, 2014 Category: Radiology Source Type: research

Telemedicine in dermatology: findings and experiences worldwide – a systematic literature review
This article is protected by copyright. All rights reserved.
Source: Journal of the European Academy of Dermatology and Venereology - May 18, 2017 Category: Dermatology Authors: L. Eissing, A. Trettel, M. Augustin Tags: Review Article Source Type: research

Bio-guided search of active indole alkaloids from Tabernaemontana catharinensis: Antitumour activity, toxicity in silico and molecular modelling studies.
Abstract Active plant metabolites have been used as prototype drugs. In this context, Tabernaemontana catharinensis (Apocynaceae) has been highlighted because of the presence of active indole alkaloids. Thus, this study aims the bio-guided search of T. catharinensis cytotoxic alkaloids. The chemical composition was identified by high-resolution mass spectrometry, and fractionation was performed by open column and preparative thin-layer chromatography, from plant stems. The enriched fractions were tested in vitro in tumour cells A375 (melanoma cell line) and A549 (adenocarcinomic human alveolar basal epithelial cel...
Source: Bioorganic Chemistry - December 15, 2018 Category: Chemistry Authors: Rosales PF, Marinho FF, Gower A, Chiarello M, Canci B, Roesch-Ely M, Paula FR, Moura S Tags: Bioorg Chem Source Type: research

169P Impact of open-label design on patient-reported outcomes (PROs) data in randomized clinical trials of immuno-oncology (IO) agents in patients with advanced or metastatic cancer: A 10-year systematic literature review (SLR)
ConclusionTo our knowledge, this SLR is the first one to focus on the impact of open-label design on PROs in randomized clinical trials of IO agents using a large search algorithm in the 3 most relevant scientific literature databases. Future research should use patient-level data to investigate potential differences in PROs between open-label and blinded trials.Legal entity responsible for the studyBristol-Myers Squibb.FundingBristol-Myers Squibb.DisclosureA. Anota: Honoraria (self), Research grant / Funding (institution), Travel / Accommodation / Expenses: Bristol-Myers Squibb. C. Lefevre: Full / Part-time employment: Br...
Source: Annals of Oncology - December 15, 2019 Category: Cancer & Oncology Source Type: research

Human blood plasma proteome mapping for search of potential markers of the lung squamous cell carcinoma.
Authors: Shevchenko VE, Kovalev SV, Arnotskaya NE, Zborovskaya IB, Akhmedov BB, Polotskii BE, Kostin AU, Moukeria AF, Zaridze DG, Davidov MI Abstract Blood plasma proteomes obtained from 77 lung squamous cell carcinoma (LSCC) patients (Stages I-III) and 67 healthy controls (all males) were analyzed by using the label-free liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the search of potential cancer biomarkers. All plasma samples were depleted of 14 highly-abundant plasma proteins by immune-affinity column chromatography before LC-MS/MS. We identified and quantified 809 differential proteins wi...
Source: European Journal of Mass Spectrometry - December 1, 2014 Category: Chemistry Tags: Eur J Mass Spectrom (Chichester, Eng) Source Type: research

Google Search Trends and Skin Cancer
Whether there is an association between population inquisitiveness in skin cancer and melanoma incidence, mortality, and the mortality to incidence ratio is unknown. Google Trends quantifies interest in topics at the population level by analyzing all search queries for a specific term, thus serving as an increasingly useful research tool. Search volume indexes (SVIs) are normalized values based on total searches during a specified period per selected region. We decided to use this innovative tool to evaluate whether population inquisitiveness on melanoma and skin cancer was correlated with a lower incidence, mortality, and...
Source: JAMA Dermatology - June 10, 2015 Category: Dermatology Source Type: research

The search for cis-regulatory driver mutations in cancer genomes.
Authors: Poulos RC, Sloane MA, Hesson LB, Wong JW Abstract With the advent of high-throughput and relatively inexpensive whole-genome sequencing technology, the focus of cancer research has begun to shift toward analyses of somatic mutations in non-coding cis-regulatory elements of the cancer genome. Cis-regulatory elements play an important role in gene regulation, with mutations in these elements potentially resulting in changes to the expression of linked genes. The recent discoveries of recurrent TERT promoter mutations in melanoma, and recurrent mutations that create a super-enhancer regulating TAL1 expression...
Source: Oncotarget - September 13, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Current studies of immunotherapy in head and neck cancer
ConclusionNumerous clinical trials are addressing the suitability and efficacy of immune checkpoint modulators in HNSCC with the predominant targets being the established immune checkpoint receptors PD‐1/PD‐L1 and CTLA‐4. Recently presented results have shown a survival benefit, a favorable safety profile and an extended duration of response in favor of using immune checkpoint modulation in R/M HNSCC.This article is protected by copyright. All rights reserved.
Source: Clinical Otolaryngology - May 2, 2017 Category: ENT & OMF Authors: Volkan Dogan, Thorsten Rieckmann, Adrian M ünscher, Chia‐Jung Busch Tags: Original Article Source Type: research

337 Estimating patient demand for Mohs surgery in the United States using Google search trends
Mohs surgeons (MS) who undergo an American College of Mohs Surgery (ACMS) accredited fellowship have intensive training needed to handle the complexities of skin cancer care. As the incidence of skin cancer rises yearly in the USA, these patients may use search engines to seek potential physicians that can help with their needs. However, this public demand for well-trained MS is currently not known. Google Trends was queried from 2004-2019 to find the average relative search volume (RSV) for the topic “Mohs Surgery” for each state.
Source: Journal of Investigative Dermatology - April 19, 2021 Category: Dermatology Authors: R. Raiker, H. Pakhchanian, N. Ganju, M. Deng Tags: Patient Population Research Source Type: research

Performance of 18 F-FDG-PET/CT as a next step in the search of occult primary tumors for patients with head and neck squamous cell carcinoma of unknown primary: a systematic review and meta-analysis
Conclusions18F-FDG PET/CT is useful as a next step in the search of occult primary tumors in HNSCC-UP patients defined by endoscopy with or without CT/MRI. However, in light of the high false-positive proportion, confirmatory histological investigations should be viewed as necessary practice upon positive PET/CT findings.
Source: Clinical and Translational Imaging - May 15, 2021 Category: Radiology Source Type: research